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modified on 12 June 2009 at 00:18 ••• 2,049 views

Arfendazam

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Arfendazam.svg.png
Arfendazam
Systematic (IUPAC) name
ethyl 7-chloro- 4-oxo- 5-phenyl- 2,3-dihydro- 1,5-benzodiazepine- 1-carboxylate
Identifiers
CAS number 37669-57-1
ATC code none
PubChem 65803
Chemical data
Formula C18H17ClN2O3 
Mol. mass 344.792
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Arfendazam is a drug which is a benzodiazepine derivative. Arfendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam. Arfendazam has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is a partial agonist at GABAA receptors, so the sedative effects are relatively mild and it produces muscle relaxant effects only at very high doses. Arfendazam produces an active metabolite lofendazam, which is thought to be responsible for part of its effects.