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modified on 31 December 2018 at 11:08 ••• 5,966 views

Bromazepam

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Bromazepam is used to treat short-term, symptomatic anxiety. Bromazepam is not used at all in United States. Bromazepam is available in Canada under the brand names Apo-Bromazepam®, Gen-Bromazepam, Lectopam®, Novo-Bromazepam and Nu-Bromazepam.


Contents

Mechanism of Action

Binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron at several sites within the central nervous system, including the limbic system, reticular formation. Enhancement of the inhibitory effect of GABA on neuronal excitability results by increased neuronal membrane permeability to chloride ions. This shift in chloride ions results in hyperpolarization (a less excitable state) and stabilization.

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Bromazepam
Systematic (IUPAC) name
9-bromo-6-pyridin-2-yl- 2,5-diazabicyclo [5.4.0]undeca- 5,8,10,12-tetraen- 3-one
Identifiers
CAS number 1812-30-2
ATC code N05BA08
PubChem 2441
DrugBank ?
ChemSpider 2347
Chemical data
Formula C14H10BrN3O 
Mol. mass 316.2
Pharmacokinetic data
Bioavailability 84%
Metabolism Hepatic
Half life 12-20 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

D (USA)

Legal status

Schedule IV(US)

Routes Oral


Overdosage Bromazepam

Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Treatment for benzodiazepine overdose is supportive. Flumazenil has been shown to selectively block the binding of benzodiazepines to CNS receptors, resulting in a reversal of benzodiazepine-induced sedation; however, its use may not reverse respiratory depression.


Legal Status Bromazepam

Bromazepam is a Schedule IV drug under the Convention on Psychotropic Substances.

Brand Names for Bromazepam

  • Akamon® (CY, HK, JO, SK)
  • Ansiogen-3® (DO, GT, HN, SV)
  • Ansiosel® (CO)
  • Ansioter® (GT, HN)
  • Anxiocalm® (BE)
  • Anxyrex® (FR)
  • Apo-Bromazepam® (CA)
  • Atemperator® (AR)
  • Benedorm® (AR)
  • Brazepam-3® (ZA)
  • Brazepam-6® (ZA)
  • Bromalex® (PT)
  • BromaLich® (DE)
  • Bromam® (DK)
  • Bromatanil® (AR)
  • Bromatop® (BE)
  • Bromaz 1A Pharma® (DE)
  • Bromazanil® (DE, LU)
  • Bromazemed® (BE)
  • Bromazepam 1A Pharma® (DE)
  • Bromazepam AL® (DE)
  • Bromazepam beta® (DE)
  • Bromazepam® (CL, CO, RO, YU)
  • Bromazepam EG® (BE)
  • Bromazepam-Eurogenerics® (LU)
  • Bromazepam Fada® (AR)
  • Bromazepam Genericon® (AT)
  • Bromazepam GNR® (IT)
  • Bromazepam Heumann® (DE)
  • Bromazepam Lannacher® (AT, RU)
  • Bromazepam L.CH.® (CL)
  • Bromazepam MK® (CR, DO, GT, HN, PA, SV)
  • Bromazepam-neuraxpharm® (DE)
  • Bromazepam-ratiopharm® (BE, DE)
  • Bromazepam Teva® (IT)
  • Bromazephar® (BE)
  • bromazep von ct® (DE)
  • Bromaze® (ZA)
  • Bromidem® (BE, LU)
  • Brozepax® (BR)
  • Calmepam® (RO)
  • Compendium® (IT)
  • Creosedin® (AR)
  • Deptran® (BR)
  • Dermatop® (BR)
  • Docbromaze® (BE)
  • durazanil® (DE)
  • Equisedin® (AR)
  • Estomina® (AR)
  • Finaten® (AR)
  • Gasmol® (AR)
  • Gen-Bromazepam (CA)
  • Gityl® (DE)
  • Lectopam® (CA)
  • Lekotam® (SI)
  • Lenitin® (IL)
  • Lentobis® (AR)
  • Lexatin® (ES)
  • Lexaurin® (CZ, HR, SI)
  • Lexilium® (CY, HR, SI, YU)
  • Lexomil® (FR)
  • Lexopam® (JO, RO)
  • Lexostad® (DE)
  • Lexotan® (AU, BE, BR, CR, DK, DO, GT, HK, HN, ID, IE, IT, LU, MX, PA, PL, PT, RO, RU, SG, SV, TH, ZA)
  • Lexotanil® (AR, AT, BD, CH, CL, CZ, DE, NL, RO)
  • Molival Bromazepam® (AR)
  • neo OPT® (DE)
  • Nervium® (BR)
  • Neurilan® (BR)
  • Neurozepam® (AR)
  • Normoc® (DE)
  • Novazepam® (BR)
  • Novo-Bromazepam (CA)
  • Nu-Bromazepam (CA)
  • Nulastres® (AR)
  • Octanyl® (AR, CO, CR, DO, GT, HN, PA, SV)
  • Placidon® (CL)
  • Quiétiline® (FR)
  • Relaxil® (BR)
  • Sedam® (PL)
  • Sipcar® (AR)
  • Somalium® (BR)
  • Totasedan® (CL)
  • Tritopan® (AR)
  • Uniao Bromazepam® (BR)