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modified on 30 December 2010 at 01:46 ••• 3,057 views

Cinolazepam

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Cinolazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Cinolazepam is not approved for sale in the United States or Canada. Cinolazepam is used for management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms.

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Cinolazepam
Systematic (IUPAC) name
3-[9-chloro- 6-(2-fluorophenyl)- 4-hydroxy- 3-oxo- 2,5-diazabicyclo [5.4.0]undeca- 5,8,10,12- tetraen- 2-yl] propanenitrile
Identifiers
CAS number 75696-02-5
ATC code N05CD13
PubChem 3033621
DrugBank ?
Chemical data
Formula C18H13ClFN3O2 
Mol. mass 357.8
Pharmacokinetic data
Bioavailability 90-100%
Metabolism Hepatic
Half life 9 h[1]
Excretion Renal
Therapeutic considerations
Pregnancy cat.

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Legal status

Unscheduled(US)

Routes Oral


Mechanism of action

Cinolazepam binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

Brand names for Cinolazepam

  • Gerodorm


Half life of Cinolazepam

9 Hours