Clorazepate
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Clorazepate is used for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.
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Pharmacology
Clorazepate is a member of the group of drugs called benzodiazepines. Pharmacologically, clorazepate has the characteristics of the benzodiazepines. It has depressant effects on the central nervous system. The primary metabolite, nordiazepam, quickly appears in the blood stream. Studies in healthy men have shown that clorazenate has depressant effects on the central nervous system. Since orally administered clorazepate dipotassium is rapidly decarboxylated to form nordiazepam, there is essentially no circulating parent drug.
Mechanism of Action
Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
Absorption
Rapidly absorbed following oral administration (bioavailability is 91%).
Toxicity
Oral LD50 in rats is 1320 mg/kg. In monkeys, oral LD50 exceed 1600 mg/kg. Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time. Protein Binding The protein binding of nordiazepam in plasma is high (97-98%).
Biotransformation
The drug is metabolized in the liver and excreted primarily in the urine. The primary metabolite, nordiazepam, is further metabolized by hydroxylation. The major urinary metabolite is conjugated oxazepam (3-hydroxynordiazepam), and smaller amounts of conjugated p-hydroxynordiazepam and nordiazepam are also found in the urine.
Half Life
The serum half-life is about 2 days. Nordiazepam, the primary metabolite, quickly appears in the blood and is eliminated from the plasma with an apparent half-life of about 40 to 50 hours.
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| Clorazepate
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| Systematic (IUPAC) name | |
| 7-chloro-2,3-dihydro-2-oxo-5-phenyl- 1H-1,4-benzodiazepine-3-carboxylic acid | |
| Identifiers | |
| CAS number | 57109-90-7 (potassium salt) |
| ATC code | N05 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C16H11ClN2O3 |
| Mol. mass | 314.72 |
| Pharmacokinetic data | |
| Bioavailability | 91% |
| Metabolism | Hepatic |
| Half life | 48 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
D(US) |
| Legal status |
Schedule IV(US) |
| Routes | Oral |
Brand names for Clorazepate
- Anksen® (TR)
- Anxielax® (TH)
- Apo-Clorazepate® (CA, SG)
- Cloramed® (TH)
- Cloranxen® (PL)
- Cloraxene® (TH)
- Clorazepate Dipotassium® (CY)
- Diposef® (TH)
- Dipot® (TH)
- Flulium® (TH)
- Justum® (AR)
- Lacort® (SI)
- Manotran® (TH)
- Medipax® (PT)
- Mendon® (JP)
- Modival® (CL)
- Noctran® (CY, EG, JO, KW, LB)
- Novo-Clopate (CA)
- Polizep® (TH)
- Pomadom® (TH)
- Posene® (TH)
- Sanor® (TH)
- Serene® (TH)
- Tencilan® (AR)
- Trancap® (TH)
- Tranclor® (TH)
- Trancon® (TH)
- Tranex® (YU)
- Transene® (IT)
- Tranxene® (BE, CY, CZ, EG)
- Tranxène® (FR)
- Tranxene® (GB, HK, IE, JO, KW, LB, LU, MX)
- Tranxène® (NL)
- Tranxene® (PL, PT, RO, RU, TH)
- Tranxilene® (BR, TR)
- Tranxilium® (AT, CH, CL, DE, ES)
- Uni-Tranxene® (BE, LU)
- Zetran-5® (TH)
U.S. Brand Names for Clorazepate
- Tranxene®
- Tranxene® SD™
- Tranxene® SD™-Half Strength
- T-Tab®