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modified on 29 April 2009 at 07:02 ••• 2,093 views

Lormetazepam

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Lormetazepam and other benzodiazepine drugs act as positive modulators at the GABAA benzodiazepine receptor complex. Lormetazepam binds to the benzodiazepine receptor which in turn enhances the effect of the GABAA receptor producing its therapeutic effects as well as adverse effects. When lormetazepam binds to the benzodiazepine receptor sites in sufficient quantities it produces sedation which is used clinically as a therapeutic treatment for insomnia. Lormetazepam alters the brain electrical activity which has been studied via EEG readings. Lormetazepam appears to be more selective in the type of benzodiazepine receptor it binds to showing a higher affinity for the omega 1 receptor which is responsible for sedation. Changes in EEG can therefore be used to measure the sedative sleep promoting properties of lormetazepam.

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Lormetazepam
Systematic (IUPAC) name
9-chloro- 6-(2-chlorophenyl)- 4-hydroxy- 2-methyl- 2,5- diazabicyclo [5.4.0] undeca- 5,8,10,12- tetraen- 3-one
Identifiers
CAS number 848-75-9
ATC code N05CD06
PubChem 13314
DrugBank ?
Chemical data
Formula C16H12Cl2N2O2 
Mol. mass 335.2 g/mol
Pharmacokinetic data
Bioavailability 80%
Metabolism Hepatic
Half life 10–12 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

D

Legal status

Schedule IV(US)

Routes Oral


Brand names for Lormetazepam

  • Noctamid
  • Ergocalm
  • Loramet
  • Dilamet
  • Sedaben
  • Stilaze
  • Nocton
  • Pronoctan
  • Noctamide
  • Loretam
  • Minias
  • Aldosomnil