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modified on 29 April 2009 at 09:00 ••• 2,909 views

Prazepam

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Prazepam is used for the treatment of anxiety disorders. Prazepam is a benzodiazepine derivative drug. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.

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Prazepam
Systematic (IUPAC) name
7-chloro- 1-(cyclopropylmethyl)- 5-phenyl- 1,3-dihydro- 2H- 1,4-benzodiazepin- 2-one
Identifiers
CAS number 2955-38-6
ATC code N05BA11
PubChem  ?
DrugBank none
Chemical data
Formula C19H17ClN2O 
Mol. mass 324.8
Synonyms 9-chloro- 2-(cyclopropylmethyl)- 6-phenyl- 2,5-diazabicyclo[5.4.0]undeca- 5,8,10,12- tetraen- 3-one
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 36-200 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?

Legal status

Schedule IV (US)

Routes Oral


Contents

Mechanism of Action

Prazepam is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation.


Toxicity

Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.


Half Life

36-200 hours


Food and Prazepam

  • Avoid alcohol.
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Avoid taking with grapefruit juice.
  • Take with food.


Dosage

Adults: Oral: 30 mg/day in divided doses, may increase gradually to a maximum of 60 mg/day.


Adverse Reactions

Frequency not defined.

Cardiovascular: Hypotension, syncope

Central nervous system: Drowsiness, fatigue, impaired coordination, lightheadedness, memory impairment, insomnia, depression, headache, anxiety, confusion, nervousness, dizziness, akathisia, ataxia, vivid dreams

Dermatologic: Rash, pruritus

Endocrine & metabolic: Decreased libido, menstrual irregularities

Gastrointestinal: Xerostomia, constipation, diarrhea, decreased salivation, nausea, vomiting, increased or decreased appetite, increased salivation, weight gain/loss

Hematologic: Blood dyscrasias

Neuromuscular & skeletal: Dysarthria, tremor, muscle cramps, rigidity, weakness, reflex slowing

Ocular: Blurred vision, increased lenticular pressure

Otic: Tinnitus

Respiratory: Nasal congestion, hyperventilation

Miscellaneous: Diaphoresis, drug dependence

Brand names for Prazepam

  • Centrax® (IE)
  • Demetrin® (AT, CH, CZ, DE, HK, PT, SI, YU, ZA)
  • Equipaz® (AR)
  • Lysanxia® (BE, FR, LU)
  • Mono Demetrin® (DE)
  • Pozapam® (TH)
  • Prasepine® (TH)
  • Prazene® (IT)
  • Reapam® (NL)
  • Trepidan® (IT)