Prazepam
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Prazepam is used for the treatment of anxiety disorders. Prazepam is a benzodiazepine derivative drug. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
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| Prazepam
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| Systematic (IUPAC) name | |
| 7-chloro- 1-(cyclopropylmethyl)- 5-phenyl- 1,3-dihydro- 2H- 1,4-benzodiazepin- 2-one | |
| Identifiers | |
| CAS number | |
| ATC code | N05 |
| PubChem | ? |
| DrugBank | |
| Chemical data | |
| Formula | C19H17ClN2O |
| Mol. mass | 324.8 |
| Synonyms | 9-chloro- 2-(cyclopropylmethyl)- 6-phenyl- 2,5-diazabicyclo[5.4.0]undeca- 5,8,10,12- tetraen- 3-one |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Hepatic |
| Half life | 36-200 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Schedule IV (US) |
| Routes | Oral |
Contents |
Mechanism of Action
Prazepam is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation.
Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Half Life
36-200 hours
Food and Prazepam
- Avoid alcohol.
- Avoid excessive quantities of coffee or tea (Caffeine).
- Avoid taking with grapefruit juice.
- Take with food.
Dosage
Adults: Oral: 30 mg/day in divided doses, may increase gradually to a maximum of 60 mg/day.
Adverse Reactions
Frequency not defined.
Cardiovascular: Hypotension, syncope
Central nervous system: Drowsiness, fatigue, impaired coordination, lightheadedness, memory impairment, insomnia, depression, headache, anxiety, confusion, nervousness, dizziness, akathisia, ataxia, vivid dreams
Dermatologic: Rash, pruritus
Endocrine & metabolic: Decreased libido, menstrual irregularities
Gastrointestinal: Xerostomia, constipation, diarrhea, decreased salivation, nausea, vomiting, increased or decreased appetite, increased salivation, weight gain/loss
Hematologic: Blood dyscrasias
Neuromuscular & skeletal: Dysarthria, tremor, muscle cramps, rigidity, weakness, reflex slowing
Ocular: Blurred vision, increased lenticular pressure
Otic: Tinnitus
Respiratory: Nasal congestion, hyperventilation
Miscellaneous: Diaphoresis, drug dependence
Brand names for Prazepam
- Centrax® (IE)
- Demetrin® (AT, CH, CZ, DE, HK, PT, SI, YU, ZA)
- Equipaz® (AR)
- Lysanxia® (BE, FR, LU)
- Mono Demetrin® (DE)
- Pozapam® (TH)
- Prasepine® (TH)
- Prazene® (IT)
- Reapam® (NL)
- Trepidan® (IT)