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modified on 30 December 2010 at 01:46 ••• 5,127 views

Flunitrazepam

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Rohypnol, A benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.

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Flunitrazepam
Systematic (IUPAC) name
6-(2-fluorophenyl)- 2-methyl- 9-nitro- 2,5-diazabicyclo [5.4.0] undeca- 5,8,10,12- tetraen- 3-one
Identifiers
CAS number 1622-62-4
ATC code N05CD03
PubChem 3380
DrugBank none
ChemSpider 3263
Chemical data
Formula C16H12FN3O3 
Mol. mass 313.3
Pharmacokinetic data
Bioavailability 50% (suppository)
64-77% (oral)
Metabolism Hepatic
Half life 18-26 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(AU)

Legal status

Controlled (S8)(AU) Class C(UK) Schedule I(US) III (International)

Routes Oral

Pharmacology

Rohypnol is a powerful hypnotic drug that is a benzodiazepine derivative. It has powerful hypnotic, sedative, anxiolytic, and skeletal muscle relaxant properties. The drug is sometimes used as a date rape drug. In the United States, the drug has not been approved by the Food and Drug Administration for medical use, and is considered to be an illegal drug. It has however been approved in the United Kingdom and other countries.

Additional information about Rohypnol

Rohypnol Indication: For short-term treatment of severe insomnias, that are not responsive to other hypnotics. Mechanism Of Action: Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.