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modified on 30 December 2010 at 01:46 ••• 5,058 views

Flunitrazepam

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Rohypnol, A benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.

Rohypnol.jpg

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Component || bgcolor="#eeeeee" | ? Class }} {{#ifeq: | combo | | bgcolor="#ddeeff" | ? Component || bgcolor="#eeeeee" | ? Class }} {{#ifeq: | combo | {{#if: | {{#ifeq: | combo | {{#if: | {{#if:3263 | {{#ifeq: | combo | | {{#ifeq: | vaccine | | | colspan="2" bgcolor="#dddddd" | Chemical data }} }} {{#ifeq: | combo | | {{#ifeq: | vaccine | | | bgcolor="#ddeeff" | Formula || bgcolor="#eeeeee" | {{#if: | {{{chemical_formula}}} | {{#if:161233 | {{OrganicBox_{{#if:16 |atom }} | atom_name={{#if:16 |Carbon }} | atom_color=rgb(000,000,000) | atom_abb=C | atom_number=16 |var1= }}{{OrganicBox_{{#if:12 |atom }} | atom_name={{#if:12 |Hydrogen }} | atom_color=rgb(77,77,77) | atom_abb=H | atom_number=12 |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Silver}} | atom_color=rgb(160,160,160) | atom_abb=Ag| atom_number={{{Ag}}} |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Arsenic}} | atom_color=rgb(101,71,120) | atom_abb=As| atom_number={{{As}}} |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Gold}} | atom_color=rgb(127,84,0) | atom_abb=Au| atom_number={{{Au}}} |var1= }}{{OrganicBox_{{#if: |atom }}| atom_name={{#if:|Boron}} | atom_color=rgb(116,82,82) | atom_abb=B | atom_number={{{B}}} |var1= }}{{OrganicBox_{{#if: |atom }}| atom_name={{#if:|Bromine}} | atom_color=rgb(83,20,20) | atom_abb=Br | atom_number={{{Br}}} |var1= }}{{OrganicBox_{{#if: |atom }}| atom_name={{#if:|Chlorine}} | atom_color=rgb(15,95,15) | atom_abb=Cl | atom_number={{{Cl}}} |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Cobalt }} | atom_color=rgb(53,59,90) | atom_abb=Co | atom_number={{{Co}}} |var1= }}{{OrganicBox_{{#if:1 |atom }} | atom_name={{#if:1 |Fluorine}} | atom_color=rgb(66,98,98) | atom_abb=F | atom_number=1 |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Gadolinium}} | atom_color=rgb(64,0,64) | atom_abb=Gd | atom_number={{{Gd}}} |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Iodine}} | atom_color=rgb(74,11,74) | atom_abb=I | atom_number={{{I}}} |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Potassium}} | atom_color=rgb(72,32,106) | atom_abb=K | atom_number={{{K}}} |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Manganese}} | atom_color=rgb(78,21,99) | atom_abb=Mn | atom_number={{{Mn}}} |var1= }}{{OrganicBox_{{#if:3 |atom }} | atom_name={{#if:3 |Nitrogen }} | atom_color=rgb(0,0,128) | atom_abb=N | atom_number=3 |var1= }}{{OrganicBox_{{#if: |atom }}| atom_name={{#if:|Sodium}} | atom_color=rgb(11,11,97) | atom_abb=Na | atom_number={{{Na}}} |var1= }}{{OrganicBox_{{#if:3 |atom }} | atom_name={{#if:3 |Oxygen}} | atom_color=rgb(116,35,35) | atom_abb=O | atom_number=3 |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Phosphorus}} | atom_color=rgb(127,63,0) | atom_abb=P | atom_number={{{P}}} |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Platinum}} | atom_color=rgb(21,53,79) | atom_abb=Pt | atom_number={{{Pt}}} |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Sulfur}} | atom_color=rgb(114,97,31) | atom_abb=S | atom_number={{{S}}} |var1= }}{{OrganicBox_{{#if: |atom }}| atom_name={{#if:|Selenium}} | atom_color=rgb(105,78,25) | atom_abb=Se | atom_number={{{Se}}} |var1= }}{{OrganicBox_{{#if: |atom }}| atom_name={{#if:|Strontium}} | atom_color=rgb(14,67,14) | atom_abb=Sr | atom_number={{{Sr}}} |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Technetium}} | atom_color=rgb(30,79,84) | atom_abb=Tc| atom_number={{{Tc}}} |var1= }}{{OrganicBox_{{#if: |atom }} | atom_name={{#if: |Zinc}} | atom_color=rgb(54,60,104) | atom_abb=Zn| atom_number={{{Zn}}} |var1= }}{{#if:|{{{charge}}}| }} | ? }} }} }} }} {{#ifeq: | combo | | {{#ifeq: | vaccine | | | bgcolor="#ddeeff" | Mol. mass || bgcolor="#eeeeee" | {{#if:313.3 | 313.3 | ? }} }} }} {{#ifeq: | combo | | {{#ifeq: | vaccine | | {{#if: | {{#ifeq: | combo | | {{#ifeq: | vaccine | | {{#if: | {{#ifeq: | combo | | {{#ifeq: | vaccine | | {{#if: | | colspan="2" bgcolor="#dddddd" | Physical data | {{#if: | | colspan="2" bgcolor="#dddddd" | Physical data | {{#if: | | colspan="2" bgcolor="#dddddd" | Physical data | {{#if: | | colspan="2" bgcolor="#dddddd" | Physical data | {{#if: | | colspan="2" bgcolor="#dddddd" | Physical data | {{#if: | | colspan="2" bgcolor="#dddddd" | Physical data }} }} }} }} }} }} }} }} {{#ifeq: | combo | | {{#ifeq: | vaccine | | {{#if: | {{#ifeq: | combo | | {{#ifeq: | vaccine | | {{#if: | {{#ifeq: | combo | | {{#ifeq: | vaccine | | {{#if: | {{#ifeq: | combo | | {{#ifeq: | vaccine | | {{#if: | {{#ifeq: | combo | | {{#ifeq: | vaccine | | {{#if: | {{#ifeq: | combo | | {{#ifeq: | vaccine | | {{#if: | {{#ifeq: | combo | | {{#ifeq: | vaccine | | | colspan="2" bgcolor="#dddddd" | Pharmacokinetic data }} }} {{#ifeq: | combo | | {{#ifeq: | vaccine | | | bgcolor="#ddeeff" style="vertical-align: top;" | Bioavailability || bgcolor="#eeeeee" | {{#if:50% (suppository)
64-77% (oral) | 50% (suppository)
64-77% (oral) | ? }} }} }} {{#ifeq: | combo | | {{#ifeq: | vaccine | | {{#if: | {{#ifeq: | combo | | {{#ifeq: | vaccine | | | bgcolor="#ddeeff" style="vertical-align: top;" | Metabolism || bgcolor="#eeeeee" | {{#if:Hepatic | Hepatic | ? }} }} }} {{#ifeq: | combo | | {{#ifeq: | vaccine | | | bgcolor="#ddeeff" style="vertical-align: top;" | Half life || bgcolor="#eeeeee" | {{#if:18-26 hours | 18-26 hours | ? }} }} }} {{#ifeq: | combo | | {{#ifeq: | vaccine | | | bgcolor="#ddeeff" style="vertical-align: top;" | Excretion || bgcolor="#eeeeee" | {{#if:Renal | Renal | ? }} }} }} {{#if: | | bgcolor="#ddeeff" | Licence data || bgcolor="#eeeeee" | | {{#if: | | bgcolor="#ddeeff" | Licence data || bgcolor="#eeeeee" | | {{#if: | | bgcolor="#ddeeff" | Licence data || bgcolor="#eeeeee" | | }} }} }} {{#if: | EU EMEA:link{{#if: | ,  }} }}{{#if: | US Daily Med:link |{{#if: | US FDA:link }} }} {{#if: |
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{{#if:Flunitrazepam-from-xtal-3D-balls.png||-

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{{#ifexist:Image:Flunitrazepam.png||-

Chemical structure of Flunitrazepam|{{#ifeq: | mab | | {{#ifeq: | combo | | {{#ifeq: | | }}}}}} }} }}
|
Flunitrazepam }}{{#ifeq: | mab | ?}}
align="center" colspan="2" bgcolor="#dddddd" | Vaccine description align="center" colspan="2" bgcolor="#dddddd" | Combination of align="center" colspan="2" bgcolor="#dddddd" | Therapeutic monoclonal antibody align="center" colspan="2" bgcolor="#dddddd" | Systematic (IUPAC) name }}
killed |Inactivated |inactivated = Killed/Inactivated attenuated = Attenuated virus live = Live bacteria toxoid = Toxoid subunit = Subunit protein subunit |Protein |protein = Protein subunit conjugate=Conjugate vaccine recombinant = Recombinant Vector dna = DNA vaccination  ? }} }}
?  ? Class

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?  ? Class

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Identifiers
CAS number {{#if:1622-62-4 | 1622-62-4 | ? }} {{#if: | }}
ATC code {{#if:N05 | N05{{#if:CD03 | CD03 }} | ? }}
PubChem {{#if:3380 | 3380 | ? }}

{{#if:none |

DrugBank none

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ChemSpider 3263

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SMILES eMolecules & PubChem

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Synonyms {{{synonyms}}}

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Density {{{density}}} g/cm³

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Melt. point {{{melting_point}}}{{#if:| –{{{melting_high}}}}} °C ({{#expr: ( {{{melting_point}}} * 9 / 5 ) + 32 round 0 }}{{#if:| –{{#expr: ( {{{melting_high}}} * 9 / 5 ) + 32 round 0 }} }} °F)

}} }} }}

Boiling point {{{boiling_point}}} °C ({{#expr: ( {{{boiling_point}}} * 9 / 5 ) + 32 round 0 }} °F)

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Solubility in water {{{solubility}}} mg/mL (20 °C)

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Spec. rot {{{specific_rotation}}}

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SEC Combust {{{sec_combustion}}}

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Protein binding {{{protein_bound}}}

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Therapeutic considerations
Pregnancy cat.

{{#if:C |

 {{#switch: C 
A = A B1 = B1 B2 = B2 B3 = B3 B = B? C = C D = D X = X  ?
 }}(AU) 

}}{{#if: |

 {{#switch:  
A = A B = B C = C D = D X = X  ?
}}(US) 

}}{{#if: | {{{pregnancy_category}}} | {{#if:C | | {{#if: | | ? }} }} }}

Legal status

{{#if:S8 |

 {{#switch: S8
Unscheduled = Unscheduled | S2 | Schedule 2 = Pharmacy Only (S2) S3 | Schedule 3 = Pharmacist Only (S3) S4 | Schedule 4 = Prescription Only (S4) S5 | Schedule 5 = Caution (S5) S6 | Schedule 6 = Poison (S6) S7 | Schedule 7 = Dangerous Poison (S7) S8 | Schedule 8 = Controlled (S8) S9 | Schedule 9 = Prohibited (S9)  ?
 }}(AU) 

}}{{#if: |

  {{#switch: 
Schedule I = Schedule I Schedule II = Schedule II Schedule III = Schedule III Schedule IV = Schedule IV Schedule V = Schedule V Schedule VI = Schedule VI Schedule VII = Schedule VII Schedule VIII= Schedule VIII  ?
 }}(CA) 

}}{{#if:Class C |

 {{#switch: Class C
GSL = GSL P =P POM = POM CD =CD Class A = Class A Class B = Class B Class C = Class C  ?
 }}(UK) 

}}{{#if:Schedule I |

 {{#switch: Schedule I
OTC = OTC Template:Unicode-only | Template:Unicode | rx | Rx | rx-only | Rx-only = [[Prescription drug|Template:Unicode-only]] Schedule I = Schedule I Schedule II = Schedule II Schedule III = Schedule III Schedule IV = Schedule IV Schedule V = Schedule V  ?
 }}(US) 

}}{{#if:III (International) |

 {{#switch: III (International)
RX | Rx | rx-only | Rx-only = Template:Unicode Prescription only III (International)
 }}

}}

Dependence Liability {{{dependency_liability}}}

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Routes {{#if:Oral | Oral | ? }}

{{#if: | |}}

Pharmacology

Rohypnol is a powerful hypnotic drug that is a benzodiazepine derivative. It has powerful hypnotic, sedative, anxiolytic, and skeletal muscle relaxant properties. The drug is sometimes used as a date rape drug. In the United States, the drug has not been approved by the Food and Drug Administration for medical use, and is considered to be an illegal drug. It has however been approved in the United Kingdom and other countries.

Additional information about Rohypnol

Rohypnol Indication: For short-term treatment of severe insomnias, that are not responsive to other hypnotics. Mechanism Of Action: Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

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