modified on 9 April 2009 at 07:18 ••• 10,401 views


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TFMPP is a synthetic piperazine often combined with BZP in Legalhighs such as Party Pills in New Zealand. TFMPPs effects alone are not very well documentated.

TFMPP powder.jpg

Consider the hip new drug trifluoromethylphenylpiperazine (TFMPP). Surprisingly, it has been reported by some to produce effects that are usually caused by entactogens such as MDMA.

Systematic (IUPAC) name
CAS number 15532-75-9
ATC code  ?
PubChem 4296
Chemical data
Formula C11H13F3N2 
Mol. mass 230.23 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism hepatic
Half life  ?
Excretion renal
Therapeutic considerations
Pregnancy cat.


Legal status
Routes oral

1-(3-trifluoromethylphenyl)piperazine is also known by the names N-(alpha,alpha,alpha-trifluoro-m-tolyl)piperazine, m-trifluormethylphenylpiperazine, TMFPP, TFMPP, and Molly [Note that Molly is also a term used for Ecstasy - Ed.]. Its chemical formula is C11H13F3N2, and its CAS number is 15532-75-9. For storage purposes, it should be kept in a closed and dark place at a temperature of 15 to 30¬į C. TFMPP is a piperazine derivative. Piperazines (also: diethylendiamines) are hygroscopic (= attract water) and heterocyclic (= contain other atoms in its cycle of carbon) compounds that have antibiotic effects. They are primarily used in veterinary medicine. Piperazines are given to chickens and pigs to control parasites such as worms (Verordnung 1990). Pharmacologically, trifluoromethylphenylpiperazine behaves in a similar manner to phenethylamines (MDMA, MDE, 2-CB, etc.) - it combines with several receptors of the 5-HT-group (serotonin-receptors; 5-HT = 5-hydroxytryptamine = serotonin).

The psychoactive effect caused by a dose taken of TFMPP is sometimes described as being somewhere between empathogens such as MDMA and entheogens such as psilocybin, mescaline, or LSD. With closed eyes, psychoptic effects are found in most cases that involve partly colored visions and patterns similar to those caused by mescaline. One's feelings may seem to be exposed, more intense, more understandable, and somehow almost touchable. However, what is considered "an active dose" of TFMPP can be highly variable and depends on the kind of effects desired. Slight empathogenic effects can be expected by taking a dose of approximately 25 mg. For a more entheogenic or visionary experience, one needs to take 75 -105 mg. Unwanted side effects may include reactions of the skin, diarrhoea or soft stool, hyperthermia (increased temperature of the body), tachycardia (increased number of heart beats), nausea, and vomiting. The Internet newsgroup alt.drugs.chemistry contains some psychonautical reports of experiences with this interesting piperazine. There is the 1997 example of Tom Kasper who owned Chemical Resale of Santa Barbara - a no longer extant company that sold psychoactive "research chemicals". [Kasper eventually did some time in jail and could still be imprisoned for all we know. -Eds.] "By accident", Kasper poured about 100 mg of TFMPP hydrochloride onto a piece of chicken that was supposed to be his dinner.


Legal Status TFMPP

TFMPP in Australia

TFMPP is controlled nationally in Australia and is also specifically listed in most Australian states. The Australian National SUSDP's rulings are automatically added to each state's laws, thus TFMPP is controlled in every Australian state. Although the state-by-state listings of chemicals is mostly a point of trivia and not very important to the legal situation, it appears that BZP and TFMPP are scheduled in the highest drug restriction schedule in Vic, NSW, SA, NT and Qld. (thanks TW of

TFMPP in Belgium

TFMPP was added to the list of illegal psychotropic substances on Nov 8, 2004 [Moniteur Belge/Belgisch Staatsblad]. Canada We have been told that BZP, TFMPP and other recreational piperazines are currently uncontrolled in Canada under the CDSA and Food and Drug Act and arent labeled under Health Canada's list of items under a stop order. (unconfirmed)

TFMPP in Germany

TFMPP is not listed in the Betäubungsmittelgesetz and is not controlled in Germany, however any psychoactive white powders may be treated as illegal by the police. (thanks S)

TFMPP in Greece

TFMPP became a controlled substance in Greece on Feb 18, 2003 [EU Legal Database].

TFMPP in Israel

In December 2007, TFMPP was added to Israel's list of controlled substances, making it illegal to buy, sell, or possess.

TFMPP in New Zealand

Sale of TFMPP, which is often mixed with vitamins and BZP, is restricted by age of purchaser. NZ's Health Department is experimenting with a novel status for some piperazines. (See Non-traditional Designer Substances: A new category of psychoactives in New Zealand, May 2004)

External Resources about TFMPP