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modified on 29 June 2011 at 16:45 ••• 11,577 views

Temazepam

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Temazepam is a benzodiazepine derivate. Temazepam is normally used for short-term treatment of insomnia (generally 7-10 days).

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killed |Inactivated |inactivated = Killed/Inactivated attenuated = Attenuated virus live = Live bacteria toxoid = Toxoid subunit = Subunit protein subunit |Protein |protein = Protein subunit conjugate=Conjugate vaccine recombinant = Recombinant Vector dna = DNA vaccination  ? }} }}
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Identifiers
CAS number {{#if:846-50-4 | 846-50-4 | ? }} {{#if: | }}
ATC code {{#if:N05 | N05{{#if:CD07 | CD07 }} | ? }}
PubChem {{#if:5391 | 5391 | ? }}

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DrugBank APRD00676

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ChemSpider 5198

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SMILES eMolecules & PubChem

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Density {{{density}}} g/cm³

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Therapeutic considerations
Pregnancy cat.

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Legal status

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Dependence Liability {{{dependency_liability}}}

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Routes {{#if:Therapeutic: Oral
Recreational Abuse: Intravenous (IV), Intramuscular (IM), Insufflated, Sprinkled in ethanol, smoked | Therapeutic: Oral
Recreational Abuse: Intravenous (IV), Intramuscular (IM), Insufflated, Sprinkled in ethanol, smoked | ? }}

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Contents

Temazepam Pharmacology

Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors. Results are sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action.


Temazepam Mechanism of Action

Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.


Temazepam Dosage

Capsule: 15 mg, 30 mg Restoril®: 7.5 mg, 15 mg, 30 mg

Recreational Dosage

?

Temazepam Absorption

Well absorbed, minimal first-pass metabolism.


Temazepam Biotransformation

Hepatic. Temazepam is completely metabolized through conjugation prior to excretion. The major metabolite is the O-conjugate of temazepam (90%).

Temazepam Half Life

10-20 hours


Temazepam Food Interactions

  • Avoid alcohol.
  • Avoid avocado.
  • Avoid excessive quantities of coffee or tea (Caffeine).

Brand names for Temazepam

  • Apo-Temazepam® (CA)
  • CO Temazepam (CA)
  • Euhypnos® (AU, BE, HK, IE, LU, NZ, TH)
  • Euipnos® (IT)
  • Gen-Temazepam (CA)
  • Levanxol® (AT, BE, LU)
  • Mabertin® (AR)
  • Nocturne® (AU)
  • Norkotral Tema® (DE)
  • Normison® (AU, BE, CH, FI, FR, HK, IE, IT, LU, NL, NZ, ZA)
  • Normitab® (NL)
  • Nortem® (IE)
  • Novo-Temazepam (CA)
  • Nu-Temazepam (CA)
  • Planum® (DE)
  • PMS-Temazepam (CA)
  • Pronervon T® (DE)
  • ratio-Temazepam (CA)
  • Remestan® (AT, DE)
  • Restoril® (CA)
  • Signopam® (HU, PL)
  • Somapam® (NZ)
  • Temador® (BE)
  • Temaze® (AU)
  • Temazepam® (GB)
  • temazep von ct® (DE)
  • Temtabs® (AU)
  • Tenox® (FI, IE)

Slang for Temazepam

  • King Kong pills (formerly referred to barbiturates, now more commonly refers to temazepam)
  • Jellies
  • Jelly
  • Edinburgh eccies
  • Tams
  • Terms
  • Mazzies
  • Temazies
  • Tammies
  • Temmies
  • Beans
  • Eggs
  • Green eggs
  • Wobbly eggs
  • Knockouts
  • Hardball
  • Norries
  • Oranges (common term in Australia and New Zealand)
  • Rugby balls
  • Ruggers
  • Terminators
  • Red and blue
  • No-gos
  • Blackout
  • Green devils
  • Drunk pills
  • Brainwash
  • Mind erasers
  • Tem-tem's (combined with buprenorphine)
  • Mommy's big helper
  • Vitamin T
  • Big T
  • TZ
  • On the nod (under the influence of heroin and temazepam together)


References

"American Academy of Pediatrics Committee on Drugs. The Transfer of Drugs and Other Chemicals Into Human Milk,"Pediatrics, 2001, 108(3):776-89.

Divoll M, Greenblatt DJ, Harmatz JS, et al, "Effect of Age and Gender on Disposition of Temazepam,"J Pharm Sci, 1981, 70(10):1104-7.

Grahame-Smith DG, "Misuse of Temazepam,"Br Med J (Clin Res Ed), 1991, 302(6786):1210.

Ho PC, Triggs EJ, Heazlewood V, et al, "Determination of Nitrazepam and Temazepam in Plasma by High Performance Liquid Chromatography,"Ther Drug Monit, 1983, 5(3):303-7.

Klotz U and Kanto J, "Pharmacokinetics and Clinical Use of Flumazenil (Ro 15-1788),"Clin Pharmacokinet, 1988, 14(1):1-12.

Mokhlesi B, Leikin JB, Murray P, et al, "Adult Toxicology in Critical Care: Part II: Specific Poisonings,"Chest, 2003, 123(3):897-922.

Scharf MB, Berkowitz DV, and Brannen DE, "Effectiveness of Low-Dose Temazepam on Sleep Patterns in Geriatric Insomniac Subjects,"Consult Pharm, 1993, 8(12):1367-73.

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