View source for LAE-32

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'''Lysergic acid ethylamide''' (also known as '''LAE-32''', '''LAE''', and '''d-ethyllysergamide''') is a lesser-known [[psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class. It is one of the least known and least researched psychedelic substances.

The pharmacology of LAE-32 is complex{{citation needed}}, but it acts primarily by binding to [[serotonin]] [[receptors]] in the brain, much like LSD and other serotonergic psychedelics.{{citation needed}}

==History and culture==
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===The CIA and Project MKULTRA Findings===
LAE-32 was experimented with by the CIA as part of Project MKULTRA. It was reported to create a condition similar to that of schizophrenia in mentally healthy individuals, characterized by indifference and depersonalization. While it was reported that, when used on schizophrenics, it created a condition that allowed the patients to become indifferent to their hallucinations and cease hallucinatory excitation.

==Chemistry==
LAE-32, or d-lysergic acid ethylamide, is a semisynthetic substance of the [[lysergamide]] family. 

Its chemical structure consists of a bicyclic hexahydroindole ring fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline an N, generally N-ethyl carboxamide is bound, LAE-32 is additionally substituted at carbon 6 with a methyl group.

==Pharmacology==
{{Further|Serotonergic psychedelic}}
LAE-32 most likely acts by binding to serotonin receptors in the brain. It may, like [[LSD]], bind to dopamine receptors as well.

==Subjective effects==
The subjective effects of LAE-32 are reportedly mainly sedating and depersonalizing, creating a state of indifference in users.

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{{effects/base

|{{effects/physical|

*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Sedation]]''' - This effect is mild compared to traditional [[sedatives]] such as [[barbiturates]] and [[benzodiazepines]].
}}
|{{effects/cognitive|

*'''[[Effect::Personal bias suppression]]'''
*'''[[Effect::Motivation suppression]]''' - LAE-32 is unique among psychedelics for its ability to suppress willpower. 
*'''[[Effect::Personality regression]]'''

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===Dangerous interactions===
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*'''[[UncertainInteraction::Cannabis]]''' - Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Extreme caution is advised when using this combination as it can significantly increase the chances of a negative psychological reaction like [[anxiety]], [[confusion]] and [[psychosis]]. Users are advised to start off with only a fraction of their usual cannabis dose and take long breaks between hits to avoid over intake.
*'''[[UncertainInteraction::Amphetamines]]''' & '''[[UncertainInteraction::Cocaine]]''' - Stimulants increase [[anxiety]] levels and the risk of [[thought loops]] which can lead to negative experiences.
*'''[[UnsafeInteraction::Tramadol]]''' - Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

==Legal status==
LAE-32 is not explicitly illegal in any nation, but it is possibly illegal to possess in the United States for purposes of consumption due to the Federal Analog Act.

==See also==
* [[Responsible use (Hallucinogens)]]
* [[Psychedelics]]
* [[Lysergamide]]
* [[LSD]]
* [[Psilocin]]
* [[Mescaline]]

==External links==
* [https://en.wikipedia.org/wiki/LAE-32 LAE-32 (Wikipedia)]
* [https://imgur.com/a/Y4CTo Project MKULTRA: LSD and LAE-32 (Imgur images of declassified CIA MKULTRA documents)]
* [https://isomerdesign.com/PiHKAL/explore.php?domain=tk&id=5311 LAE-32 (TiHKAL / Isomer Design)]

==References==
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[[Category:Psychoactive substance]]
[[Category:Entheogen]]
[[Category:Hallucinogen]]
[[Category:Psychedelic]]
[[Category:Lysergamide]]
[[Category:Approval]]
[[Category:Proofread]]
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