View source for Talk:Agmatine


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{{SummarySheet}}
{{SubstanceBox/Example}}

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==History and culture==
{{historyStub}}

==Chemistry==
{{chemistry}}
==Pharmacology==
{{pharmacology}}
Agmatine acts as an [[NMDA]] receptor antagonist, a2 adrenergic receptor antagonist, and imidazoline receptor agonist.<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748779/ Crespi (2019) Comparative psychopharmacology of autism and psychotic-affective disorders suggests new targets for treatment]</ref>
==Subjective effects==
{{EffectStub}}
{{Preamble/SubjectiveEffects}}
{{effects/base

|{{effects/physical|
If applicable, a brief paragraph summary of the substance's physical effects may be included here. 

You may select physical effects to add below [[Subjective effect index#Physical effects|here]].

*'''[[Effect::Pain relief]]'''<ref>[https://www.researchgate.net/profile/Tayfun-Uzbay/publication/51619445_The_pharmacological_importance_of_agmatine_in_the_brain/links/5a3c04590f7e9b10e23bb734/The-pharmacological-importance-of-agmatine-in-the-brain.pdf?_sg%5B0%5D=started_experiment_milestone&origin=journalDetail Uzbay (2011) The Pharmacological Importance of Agmatine in the Brain]</ref> 
*'''[[Effect::Stimulation]] or [[Effect::Sedation]]''' - Some individuals experience mild stimulation from agmatine, while others report mild sedation
*'''[[Effect::Nausea]]''' - This effect is more prominent at high doses
*'''[[Effect::Stomach bloating]]''' - This effect is more prominent at high doses
*'''[[Effect::Vasodilation]]''' - Agmatine is shown to be a potent vasodilator, and is commonly supplemented by body builders for this purpose<ref>[https://www.sciencedirect.com/science/article/pii/0024320595020117 Gao et al. (1995) Agmatine: A Novel Endogenous Vasodilator Substance]</ref>
*'''[[Effect::Physical euphoria]]'''
*'''[[Effect::Muscle relaxation]]'''
*'''[[Hypogylcemia]]'''




}}
{{effects/visual|
If applicable, a brief paragraph summary of the substance's visual effects may be included here. 

You may select visual effects to add below [[Subjective effect index#Visual effects|here]].

====Enhancements====
*'''[[Effect::Visual acuity effect1]]'''

====Distortions====
*'''[[Effect::Visual distortion effect1]]'''

====[[Effect::Geometry]]====
If applicable, a brief paragraph summary describing the visual geometry produced by the substance may be included here.
====Hallucinatory states====
If applicable, a brief summary of the substance's visual effects profile may be written here.

*'''[[Effect::Hallucinatory states1]]'''

}}

|{{effects/cognitive|
If applicable, a brief paragraph summary of the substance's cognitive effects may be included here. 

You may select from a list of cognitive effects to add below [[Subjective effect index#Cognitive effects|here]].

*'''[[Effect::Psychosis]]''' - Increased blood agmatine is associated with psychosis, and the administration of agmatine increases cognitive markers of psychosis <ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748779/ Crespi (2019) Comparative psychopharmacology of autism and psychotic-affective disorders suggests new targets for treatment]</ref>, however it is unlikely in regular doses to produce psychotic symptoms in healthy individuals
*'''[[Effect::Anxiety suppression]]'''<ref>[https://www.researchgate.net/profile/Tayfun-Uzbay/publication/51619445_The_pharmacological_importance_of_agmatine_in_the_brain/links/5a3c04590f7e9b10e23bb734/The-pharmacological-importance-of-agmatine-in-the-brain.pdf?_sg%5B0%5D=started_experiment_milestone&origin=journalDetail Uzbay (2011) The Pharmacological Importance of Agmatine in the Brain]</ref>
*'''[[Effect::Motivation enhancement]]''' 
*'''[[Effect::Addiction suppression]]''' - Agmatine has shown to have remarkable efficacy in reducing the withdrawal symptoms of several different classes of addictive substances, as well as reducing addictive behaviors<ref>[https://www.researchgate.net/profile/Tayfun-Uzbay/publication/51619445_The_pharmacological_importance_of_agmatine_in_the_brain/links/5a3c04590f7e9b10e23bb734/The-pharmacological-importance-of-agmatine-in-the-brain.pdf?_sg%5B0%5D=started_experiment_milestone&origin=journalDetail Uzbay (2011) The Pharmacological Importance of Agmatine in the Brain]</ref> 
*'''[[Effect::Empathy, affection, and sociability enhancement]]''' - This effect is milder when compared to substances such as [[MDMA]]
*'''[[Emotion enhancement]]''' - Agmatine is anecdotally reported to enhance positive emotions and reduce anhedonia, however some users report mild anhedonia from taking agmatine
*'''[[Dream potentiation]]'''
*'''[[Cognitive euphoria]]''' - This effect is milder in comparison to other dissociatives such as [[DXM]]
*'''[[Increased music appreciation]]'''
*'''[[Increased libido]]''' or '''[[Decreased libido]]'''
*'''[[Insomnia]]''' - Agmatine produces insomnia in some individuals when taken late in the day





}}
{{effects/auditory|
If applicable, a brief paragraph summary of the substance's auditory effects may be included here. 

You may select from a list of auditory effects to add below [[Subjective effect index#Auditory effects|here]].

*'''[[Effect::Auditory effect1]]'''
*'''[[Effect::Auditory effect2]]'''

}}
{{effects/multisensory|
If applicable, a brief paragraph summary of the substance's multisensory effects may be included here. 

You may select from a list of multisensory effects to add below [[Subjective effect index#Multisensory effects|here]].

*'''[[Effect::Multisensory effect1]]''' 
*'''[[Effect::Multisensory effect2]]''' 

}}
{{effects/transpersonal|
If applicable, a brief paragraph summary of the substance's transpersonal effects may be included here. 

You may select from a list of transpersonal effects to add below [[Subjective effect index#Transpersonal effects|here]].

*'''[[Effect::Transpersonal effect1]]'''
*'''[[Effect::Transpersonal effect2]]'''

}}
}}
===Experience reports===
There are currently {{#ask:[[Category:SUBSTANCE]][[Category:Experience]] | format=count}} experience reports which describe the effects of this substance in our [[experience index]].
{{#ask: [[Category:SUBSTANCE]][[Category:Experience]]|format=ul|Columns=1}}
Additional experience reports can be found here:
* [https://www.erowid.org/experiences/subs/exp_SUBSTANCE.shtml Erowid Experience Vaults: SUBSTANCE] <!-- Check the link to see if it exists -->

==Toxicity and harm potential==
{{toxicity}}
It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance.
===Lethal dosage===
===Tolerance and addiction potential===
===Dangerous interactions===
{{DangerousInteractions}}
{{DangerousInteractions/Intro}}

==Legal status==
{{LegalStub}}

==See also==
*[[Responsible use]]

==External links==
(List along order below)
* [https://en.wikipedia.org/wiki/SUBSTANCE SUBSTANCE (Wikipedia)]
* SUBSTANCE (Erowid Vault)
* SUBSTANCE ([''PiHKAL'' or ''TiHKAL''] / Isomer Design)

==Literature==
* APA formatted reference 

Please see the [[citation formatting guide]] if you need assistance properly formatting citations.

==References==
<references />

[[Category:Psychoactive substance]][[Category:Proofread]][[Category:Approval]][[Category:Nootropic]][[Category:Dissociative]]