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[[File:3meopcp.jpg|right|3-MeO-PCP in a pill form]]

'''3-Methoxyphencyclidine''' (3-MeO-PCP) is a dissociative anesthetic drug that is sold online as a research chemical.
The effects are often described as being more euphoric and mentally clearer than many related compounds.

== History ==

A 1965 article published by Maddox described the synthesis of 2-MeO-PCP and 4-MeO-PCP. Preparation of 3-MeO-PCP was described later in 1979 by Geneste et al.

The compound was first synthesized in 1979 to investigate the structure-activity relationship of phencyclidine derivatives. The activity of 3-MeO-PCP in man was not described until 1999 when a chemist using the pseudonym John Q. Beagle wrote that 3-MeO-PCP was qualitatively similar to PCP with comparable potency.

== Dosage ==

3-MeO-PCP, like PCP is active in the single milligram range and therefor can be hard to accurately measure.

'''Most if not all consumer-grade jewelry-scales advertised as working at the 0.001g (mg) range are not reliably accurate enough to measure quantities weighing less than around 15-25 mg depending on the model and calibration.
With a drug as potent as 3-MeO-PCP a small discrepancy in measurement can make a world of difference in physical and mental response to the dose.
It is for these reasons that it would be in one's best interest to use a [https://wiki.tripsit.me/wiki/Quick_Guide_to_Volumetric_Dosing volumetric dose measurement technique as outlined in this guide.]'''

{| class="wikitable"

|+ Oral

|-

| Threshold || 1.5-3 mg

|-

| Light || 3-5 mg

|-

| Common || 5-10 mg

|-

| Strong || 10-15 mg

|-

| Heavy || 15-18 mg+

|}

{| class="wikitable"

|+ Insufflated

|-

| Threshold || 1-2 mg

|-

| Light || 2-5 mg

|-

| Common || 5-8 mg

|-

| Strong || 8-12 mg

|-

| Heavy || 12-15 mg+

|}

= Duration =

{| class="wikitable"

|+ Oral

|-

| Onset || 20-40 minutes

|-

| Total || 3-5 hours +/- 60 minutes, dependent on dose.

|-

| After-effects || 2-48 hours

|}

{| class="wikitable"

|+ Insufflated

|-

| Onset || 10-30 minutes

|-

| Total || 2-4 hours +/- ~30 minutes, dependent on dose.

|-

| After-effects || 2-48 hours

|}

== Effects ==

=== Positive ===

* Increase in energy / stimulation

* Euphoria

* Pleasant mental and/or body high

* Music appreciation

* Disconnected thoughts

* Sense of calm

* Increased sociability, loss of inhibitions

* Closed and open-eye visuals

* Shifts in perception of reality

=== Neutral ===

* Increased heart rate (lower doses)

* Altered time perception

* Disrupted speech patterns

* Analgesia (decreased pain awareness) and numbness

* Distorted sensory perceptions, hallucinations

* Unusual and unpredictable behavior

* Mild to moderate dissociation

* Confusion, disorientation

=== Negative ===

* Disturbing hallucinations and/or delusions

* Anxiety, paranoia

* Severe dissociation, depersonalization

* Ataxia (loss of motor coordination)

* Psychotic episodes

* Nausea, vomiting

* Temporary amnesia

* Severe distortion or loss of auditory/visual perception

== Harm Reduction ==

* 3-Meo-PCP is a very powerful NMDA antagonist (doses are on par with [[PCP]]), and as such it has the potential to be very confusing.
* 3-MeO-PCP is considered to be a 'research-chemical', simply meaning that there is little to no clinical data on long-term effects.
* 3-MeO-PCP, as with all arylcyclohexylamine class dissociative compounds may cause neurotoxicity when used frequently or in high dose.
* 3-MeO-PCP acts as a mild Serotonin Reuptake Inhibitor and as such may risk adverse effects as a result of synergy when used with certain serotogenic drugs or medications. See [http://wiki.tripsit.me/wiki/3-MeO-PCP#Interactions Interactions].
* It is difficult to measure 3-MeO-PCP accurately with a scale because it is active in the 1-10 mg range. See [http://wiki.tripsit.me/wiki/3-MeO-PCP#Dosage the dosage section] for more information.
* 3-MeO-PCP has a steep dose-response-curve and an onset ranging from approximately 20-40 minutes. It is inadvisable to redose, especially within the first hour.

For more information see [http://wiki.tripsit.me/wiki/Dissociatives#Harm_Reduction Dissociative Harm-Reduction].

=== Interactions ===

Check out our [[Drug Combinations]] page and chart for interactions and combinations of common drugs.
PCP and 3-MeO-PCP have similar profiles and as such its safe to assume the PCP combination-chart data also applies to 3-MeO-PCP.

Specifically, do not mix 3-MeO-PCP with alcohol or benzodiazepines. 3-MeO-PCP will also likely produce synergistic effects if used in conjunction with certain serotogenic medications or drugs.

== Chemistry and Pharmacology ==

3-MeO-PCP binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions, followed by 2-MeO-PCP and 4-MeO-PCP. It is also a Serotonin Reuptake Inhibitor (SRI).

3-MeO-PCP hydrochloride is a white crystalline solid with a melting point of 204-205°C.

3-MeO-PCP has a Ki of 20 nM for the NMDA receptor, 216 nM for the serotonin transporter and 42 for the sigma1 receptor.

== Legal status ==

UK: Class B, as are all arylcyclohexamines.

US: Covered by the analogue act if sold for human consumption.

== Links ==

[https://en.wikipedia.org/wiki/3-MeO-PCP Wikipedia]

[http://www.vice.com/read/interview-with-ketamine-chemist-704-v18n2 Interview with a Ketamine Chemist]

[http://onlinelibrary.wiley.com/doi/10.1002/dta.1620/abstract From MXE to PCP]

[[Category:Drugs]]

[[Category:Dissociative]]

[[category:Research Chemical]]

3-MeO-PCP - Revision history

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