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'''Lysergic acid ethylamide''' (also known as '''LAE-32''', '''LAE''', and '''d-ethyllysergamide''') is a lesser-known [[psychoactive class::psychedelic]] substance of the [[chemical class::lysergamide]] class. It is one of the least known and least researched psychedelic substances.<br />
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The pharmacology of LAE-32 is complex{{citation needed}}, but it acts primarily by binding to [[serotonin]] [[receptors]] in the brain, much like LSD and other serotonergic psychedelics.{{citation needed}}<br />
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==History and culture==<br />
{{historyStub}}<br />
===The CIA and Project MKULTRA Findings===<br />
LAE-32 was experimented with by the CIA as part of Project MKULTRA. It was reported to create a condition similar to that of schizophrenia in mentally healthy individuals, characterized by indifference and depersonalization. While it was reported that, when used on schizophrenics, it created a condition that allowed the patients to become indifferent to their hallucinations and cease hallucinatory excitation.<br />
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==Chemistry==<br />
LAE-32, or d-lysergic acid ethylamide, is a semisynthetic substance of the [[lysergamide]] family. <br />
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Its chemical structure consists of a bicyclic hexahydroindole ring fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline an N, generally N-ethyl carboxamide is bound, LAE-32 is additionally substituted at carbon 6 with a methyl group.<br />
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==Pharmacology==<br />
{{Further|Serotonergic psychedelic}}<br />
LAE-32 most likely acts by binding to serotonin receptors in the brain. It may, like [[LSD]], bind to dopamine receptors as well.<br />
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==Subjective effects==<br />
The subjective effects of LAE-32 are reportedly mainly sedating and depersonalizing, creating a state of indifference in users.<br />
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{{Preamble/SubjectiveEffects}}<br />
{{effects/base<br />
<br />
|{{effects/physical|<br />
<br />
*'''[[Effect::Pupil dilation]]'''<br />
*'''[[Effect::Sedation]]''' - This effect is mild compared to traditional [[sedatives]] such as [[barbiturates]] and [[benzodiazepines]].<br />
}}<br />
|{{effects/cognitive|<br />
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*'''[[Effect::Personal bias suppression]]'''<br />
*'''[[Effect::Motivation suppression]]''' - LAE-32 is unique among psychedelics for its ability to suppress willpower. <br />
*'''[[Effect::Personality regression]]'''<br />
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}}<br />
}}<br />
===Dangerous interactions===<br />
{{DangerousInteractions/Intro}}<br />
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*'''[[UncertainInteraction::Cannabis]]''' - Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Extreme caution is advised when using this combination as it can significantly increase the chances of a negative psychological reaction like [[anxiety]], [[confusion]] and [[psychosis]]. Users are advised to start off with only a fraction of their usual cannabis dose and take long breaks between hits to avoid over intake.<br />
*'''[[UncertainInteraction::Amphetamines]]''' & '''[[UncertainInteraction::Cocaine]]''' - Stimulants increase [[anxiety]] levels and the risk of [[thought loops]] which can lead to negative experiences.<br />
*'''[[UnsafeInteraction::Tramadol]]''' - Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.<br />
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==Legal status==<br />
LAE-32 is not explicitly illegal in any nation, but it is possibly illegal to possess in the United States for purposes of consumption due to the Federal Analog Act.<br />
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==See also==<br />
* [[Responsible use (Hallucinogens)]]<br />
* [[Psychedelics]]<br />
* [[Lysergamide]]<br />
* [[LSD]]<br />
* [[Psilocin]]<br />
* [[Mescaline]]<br />
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==External links==<br />
* [https://en.wikipedia.org/wiki/LAE-32 LAE-32 (Wikipedia)]<br />
* [https://imgur.com/a/Y4CTo Project MKULTRA: LSD and LAE-32 (Imgur images of declassified CIA MKULTRA documents)]<br />
* [https://isomerdesign.com/PiHKAL/explore.php?domain=tk&id=5311 LAE-32 (TiHKAL / Isomer Design)]<br />
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==References==<br />
{{reflist|2}}<br />
[[Category:Psychoactive substance]]<br />
[[Category:Entheogen]]<br />
[[Category:Hallucinogen]]<br />
[[Category:Psychedelic]]<br />
[[Category:Lysergamide]]<br />
[[Category:Approval]]<br />
[[Category:Proofread]]<br />
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