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modified on 12 June 2009 at 00:01 ••• 2,789 views

Levomethorphan

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Levomethorphan.png
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Levomethorphan
Systematic (IUPAC) name
3-methoxy-17-methylmorphinan
Identifiers
CAS number 125-68-8
ATC code R05DA09
PubChem 5486607
DrugBank APRD00655
Chemical data
Formula C18H25NO 
Mol. mass 271.397 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 3-6 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

Schedule II

Routes  ?

Levomethorphan is a drug very rarely used. It is the l-stereoisomer of methorphan. The effects of the two isomers are quite different. Dextromethorphan is an antitussive at low doses and a dissociative at much higher doses, whereas levomethorphan is an opioid analgesic. Levomethorphan has effects similar to levorphanol but is less potent as it must be demethylated to the active form by liver enzymes before becoming active.