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modified on 6 April 2009 at 10:07 ••• 2,112 views

MDCPM

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MDCPM

MDCPM
MDCPM.png
IUPAC name
Identifiers
SMILES
Properties
Molecular formula C14H21NO2
Molar mass 235.325 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox references

CYCLOPROPYLMETHYL-MDA; 3,4-METHYLENEDIOXY-N-CYCLOPROPYLMETHYLAMPHETAMINE

Contents

SYNTHESIS

A solution of 9.4 g cyclopropylmethylamine hydrochloride in 30 mL MeOH was treated with 1.8 g 3,4-methylenedioxyphenylacetone (see under MDMA for its preparation) followed by 0.5 g sodium cyanoborohydride. Concentrated HCl was added as needed to keep the pH constant at about 6. After several days stirring, the reaction mixture was added to H2O, acidified with HCl, and washed with 2x100 mL CH2Cl2. The aqueous phase was made basic with 25% NaOH, and extracted with 3x150 mL CH2Cl2. Removal of the solvent from these extracts under vacuum yielded 2.8 g of a crude product which, on distillation at 90-100 °C at 0.1 mm/Hg, yielded 0.4 g of a clear white oil. This was dissolved in a small amount of IPA, neutralized with a few drops of concentrated HCl, and diluted with anhydrous Et2O to the point of turbidity. There was obtained a small yield of crystalline 3,4-methylenedioxy-N-cyclopropylmethylamphetamine hydrochloride (MDCPM) which was filtered off, Et2O washed and air dried. The mp was 218-220 °C, with extensive darkening just prior to melting. Anal. (C14H20ClNO2) N.


DOSAGE

greater than 10 mg.


DURATION

unknown.


EXTENSIONS AND COMMENTARY

The record of the tasting assay of this compound is pretty embarrassing. The highest level tried was 10 milligrams, which showed no hint of activity. But in light of the rather colorful activities of other cyclopropylmethyl things such as CPM and 2C-T-8 , this compound might someday warrant reinvestigation. It is a certainty that the yield could only be improved with a careful resynthesis.