modified on 30 December 2010 at 01:46 ••• 4,964 views


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Cinolazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Cinolazepam is not approved for sale in the United States or Canada. Cinolazepam is used for management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms.

Systematic (IUPAC) name
3-[9-chloro- 6-(2-fluorophenyl)- 4-hydroxy- 3-oxo- 2,5-diazabicyclo [5.4.0]undeca- 5,8,10,12- tetraen- 2-yl] propanenitrile
CAS number 75696-02-5
ATC code N05CD13
PubChem 3033621
DrugBank ?
Chemical data
Formula C18H13ClFN3O2 
Mol. mass 357.8
Pharmacokinetic data
Bioavailability 90-100%
Metabolism Hepatic
Half life 9 h[1]
Excretion Renal
Therapeutic considerations
Pregnancy cat.


Legal status


Routes Oral

Mechanism of action

Cinolazepam binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

Brand names for Cinolazepam

  • Gerodorm

Half life of Cinolazepam

9 Hours