modified on 2 January 2019 at 13:30 ••• 3,624 views


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Systematic (IUPAC) name
8-chloro- 1-phenyl- 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-one
CAS number 29176-29-2
ATC code  ?
PubChem 71709
Chemical data
Formula C15H13ClN2O 
Mol. mass 272.73
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Lofendazam is used for the treatment of anxiety and neuroses including psychosomatic disturbances and as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.

Lofendazam is an organic molecule which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam.