Clobazam

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Clobazam
Systematic (IUPAC) name
7-Chloro- 1-methyl- 5-phenyl- 1,5-benzodiazepine- 2,4(3H)-dione
Identifiers
CAS number	22316-47-8
ATC code	N05BA09
PubChem	2789
DrugBank	APRD00307
Chemical data
Formula	C16H13ClN2O2
Mol. mass	300.74
Pharmacokinetic data
Bioavailability	90%
Protein binding	83%
Metabolism	Hepatic
Half life	18 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status	Schedule IV (US) Class C (New Zealand)[1] Class C/Sch.4 (UK)
Routes	Oral

Clobazam is the generic name of the brand-name drug commonly known as Frisium. Clobazam is a seizure medicine and is available in many countries outside the United States. In Canada, clobazam is also sold under the brand name Novo-Clobazam.

The first benzodiazepines were synthesized in 1933 and were more fully developed in the 1950s. Clobazam (Frisium) was not developed until the 1970s. It has a subtle chemical difference from earlier benzodiazepines used to treat seizures, such as clonazepam (Klonopin), lorazepam (Ativan), diazepam (Valium), and chlorazepate (Tranxene). This difference may lead to less of a problem with tolerance with clobazam than with other benzodiazepines. Today, clobazam is approved for use in almost all countries except the United States.

In April, 2004, Ovation Pharmaceuticals announced that it had arranged to buy the North American rights to clobazam (Frisium) and planned to try to get FDA approval for sale in the United States. This process is likely to take 3 to 5 years, however.

Clobazam is not sold in the United States. The name or appearance may differ from country to country, but the dose (measured in milligrams, abbreviated "mg") will usually be the same. In Canada, Australia, the UK, and elsewhere, it is available as a 10-mg white tablet.

Contents 1 Availability 2 Side effects of Clobazam 2.1 Common 2.2 Rare 3 Drug Interactions 4 External links

Availability

Clobazam is available in oral form only, due to its insolubility in water.

Side effects of Clobazam

Common

• Ataxia
• Somnolence
• Diplopia
• Dysarthria

Rare

• Gelastic seizures
• Urticaria
• Rashes

Drug Interactions

• Alcohol increases bioavailability by 50%
• Cimetidine increases the effects of clobazam

External links

• Inchem - Clobazam

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