Lormetazepam
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Lormetazepam and other benzodiazepine drugs act as positive modulators at the GABAA benzodiazepine receptor complex. Lormetazepam binds to the benzodiazepine receptor which in turn enhances the effect of the GABAA receptor producing its therapeutic effects as well as adverse effects. When lormetazepam binds to the benzodiazepine receptor sites in sufficient quantities it produces sedation which is used clinically as a therapeutic treatment for insomnia. Lormetazepam alters the brain electrical activity which has been studied via EEG readings. Lormetazepam appears to be more selective in the type of benzodiazepine receptor it binds to showing a higher affinity for the omega 1 receptor which is responsible for sedation. Changes in EEG can therefore be used to measure the sedative sleep promoting properties of lormetazepam.
Lormetazepam
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Systematic (IUPAC) name | |
9-chloro- 6-(2-chlorophenyl)- 4-hydroxy- 2-methyl- 2,5- diazabicyclo [5.4.0] undeca- 5,8,10,12- tetraen- 3-one | |
Identifiers | |
CAS number | |
ATC code | N05 |
PubChem | |
DrugBank | |
Chemical data | |
Formula | C16H12Cl2N2O2 |
Mol. mass | 335.2 g/mol |
Pharmacokinetic data | |
Bioavailability | 80% |
Metabolism | Hepatic |
Half life | 10–12 hours |
Excretion | Renal |
Therapeutic considerations | |
Pregnancy cat. |
D |
Legal status | |
Routes | Oral |
Brand names for Lormetazepam
- Noctamid
- Ergocalm
- Loramet
- Dilamet
- Sedaben
- Stilaze
- Nocton
- Pronoctan
- Noctamide
- Loretam
- Minias
- Aldosomnil