Flutoprazepam: Difference between revisions

Flutoprazepam is a benzodiazepine derivative. It was discovered in Japan in 1972, and its mostly confined to that country even today. Flutoprazepam is around four times more potent by weight compared to diazepam.


Flutoprazepam
Systematic (IUPAC) name
7-chloro-1-cyclopropylmethyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one
Identifiers
CAS number	25967-29-7
ATC code	?
PubChem	3400
Chemical data
Formula	C₁₉H₁₆Cl F N₂O
Mol. mass	342.795
Pharmacokinetic data
Bioavailability	80-90%
Metabolism	Hepatic
Half life	60-90 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	X(US)
Legal status	Schedule IV(US)
Routes	Oral, Intravenous

Abuse of benzodiazepines in Japan is extremely common, with flutoprazepam being one of the most commonly abused, along with the benzodiazepines of abuse nimetazepam, temazepam, and triazolam.

Benzodiazepines (N05BA, N05CD)

1,4-Benzodiazepines	Bromazepam • Camazepam • Chlordiazepoxide • Cinolazepam • Clonazepam • Clorazepate • Cyprazepam • Delorazepam • Diazepam • Doxefazepam • Elfazepam • Ethyl carfluzepate • Ethyl dirazepate • Ethyl loflazepate • Fletazepam • Fludiazepam • Flunitrazepam • Flurazepam • Flutemazepam • Flutoprazepam • Fosazepam • Gidazepam • Halazepam • Iclazepam • Lopirazepam • Lorazepam • Lormetazepam • Meclonazepam • Medazepam • Menitrazepam • Metaclazepam • Nimetazepam • Nitrazepam • Nitrazepate • Nordazepam • Oxazepam • Phenazepam • Pinazepam • Pivoxazepam • Prazepam • Proflazepam • Quazepam • QH-II-66 • Reclazepam • Sulazepam • Temazepam • Tetrazepam • Uldazepam

1,5-Benzodiazepines	Arfendazam • Clobazam • Lofendazam • Triflubazam • Zomebazam

2,3-Benzodiazepines	Girisopam • GYKI-52466 • GYKI-52895 • Nerisopam • Tofisopam

Triazolobenzodiazepines	Adinazolam • Alprazolam • Estazolam • Triazolam

Imidazobenzodiazepines	Bretazenil • Climazolam • Flumazenil • Imidazenil • L-655,708 • Loprazolam • Midazolam • PWZ-029 • Ro15-4513 • Ro48-6791 • Sarmazenil • SH-053-R-CH3-2′F

Oxazolobenzodiazepines	Cloxazolam • Flutazolam • Haloxazolam • Mexazolam • Oxazolam

Thienodiazepines	Brotizolam • Ciclotizolam • Clotiazepam • Etizolam

Pyridodiazepines	Zapizolam • Lopirazepam

Pyrazolodiazepines	Ripazepam • Zolazepam

Pyrrolodiazepines	Premazepam

Benzodiazepine Prodrugs	Avizafone • Rilmazafone

Others	Bentazepam • Devazepide • Ketazolam • Razobazam • Tifluadom

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Latest revision as of 15:18, 29 October 2025