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Diazepam (Also known as Diastat; Valium; Zetran) is a [[Benzodiazepines|benzodiazepine]] that is commonly used to treat a large range of conditions from anxiety to Meniere’s Disease. It possesses anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnesic properties. It is also one of the most commonly used drugs to taper off of other [[Benzodiazepines|benzodiazepines]]/[[Alcohol]] withdrawal.
'''Diazepam''' is actually pretty much the same as Valium. '''Diazepam''' is a mild tranquilizer in the class of drugs known as benzodiazepines. The generic form of this drug is also available.


[[File:Diazepam10mg.jpg|thumb|Diazepam 10mg tabs]]


= History =
== Use of Diazepam ==


Diazepam was the second [[Benzodiazepines|benzodiazpine]] (The first of which was Librium) invented by Dr. Leo Sternbach of Hoffmann-La Roche at the company’s Nutley, New Jersey, facility. It was released in 1963 as an improved version of Librium, it became incredibly popular.
Diazepam is used on a short-term basis to treat patients with mild to moderate anxiety. It is also used to treat some types of seizures (epilepsy), muscle spasms, nervous tension, and symptoms relating to alcohol withdrawal.
Diazepam was the top-selling pharmaceutical in the United States from 1969 to 1982, with peak sales in 1978 of 2.3 billion tablets.
Description


= Formulations =
Diazepam is one of many chemically-related tranquilizers in the class of drugs called benzodiazepines. Benzodiazepines are sedative-hypnotic drugs that help to relieve nervousness, tension, and other anxiety symptoms by slowing the central nervous system. To do this, they block the effects of a specific chemical involved in the transmission of nerve impulses in the brain, decreasing the excitement level of the nerve cells. All benzodiazepines, including diazepam, cause sedation, drowsiness, and reduced mental and physical alertness.
It is available in instant release formulations of 2mg, 5mg, and 10mg tablets.
Recommended dosage


It is also available in an oral solution of 5mg/5ml (1mg/ml)
The typical dose of diazepam used to treat anxiety or seizures in healthy adults ranges from a total of 6 milligrams (mg) to 40 mg per day given in three or four doses. Elderly people (over age 60) are usually given lower doses in the range of 4–10 mg per day to treat anxiety or nervous tension. For acute treatment of seizures, a higher dose of diazepam is given intravenously (directly into the vein) only in a controlled medical setting such as a hospital or emergency room. For alcohol withdrawal, the typical dose is a total of 30–40 mg per day given in three or four doses.


The typical dose for a child over age six months with anxiety or seizures is a total of 3–10 mg per divided into several doses. In general, children receive lower doses of diazepam even when they have a body weight equivalent to a small adult. Diazepam is usually taken as a pill, but an injectable form is sometimes used when a serious seizure is in progress or when muscle spasms are severe. There is also a liquid oral form of the drug available.


= Doses =
{{Drugbox|
| IUPAC_name = 7-chloro-1,3dihydro-1-methyl-<br/>5-phenyl-2''H''-<br/>1,4-benzodiazepin-2-one
| image = Diazepam structure.svg.png
| width = 180
| image2 = Diazepam-from-xtal-3D-balls.png
| CAS_number = 439-14-5
| ChemSpiderID = 2908
| ATC_prefix = N05
| ATC_suffix = BA01
| ATC_supplemental = {{ATC|N05|BA17}}
| PubChem = 3016
| DrugBank = APRD00642
| C = 16 | H = 13 | Cl = 1 | N = 2 | O = 1
| molecular_weight = 284.7 g/mol
| molar_refractivity = 80.91 ± 0.5 cm³
| bioavailability = 93%
| metabolism = [[Liver|Hepatic]] - [[CYP2C19]]
| elimination_half-life = 20–100 hours
| excretion = [[Kidney|Renal]]
| pregnancy_AU = C
| pregnancy_US = D
| legal_status = [[Schedule IV controlled substance|Schedule IV]] (International)
| legal_US = Schedule IV
| legal_AU = S4
| legal_CA = Schedule IV
| routes_of_administration = Oral, [[Intramuscular injection|IM]], [[Intravenous therapy|IV]], [[suppository]]
}}


NOTE: Higher doses have an increased risk of blacking out.


{| class="wikitable"
== Precautions ==
|+ Oral
| Light || 2.5-5mg


|-
The elderly, children, and those with significant health problems need to be carefully evaluated before receiving diazepam. Children under the age of six months should not take diazepam. In addition, people with a history of liver disease, kidney disease, or those with low levels of a protein in the blood called albumin need to be carefully assessed before starting this drug.


| Common || 5-15mg
People taking diazepam should not drive, operate dangerous machinery, or engage in hazardous activities that require mental alertness, because diazepam can cause drowsiness. Alcohol and any drugs that treat mental illness should not be used when taking this medication. People who have previously had an allergic reaction to any dosage level of diazepam or any other benzodiazepine drug should not take diazepam. People with acute narrow-angle glaucoma should not take diazepam.


|-
The prescribing physician should be consulted regularly if diazepam is taken consistently for more than two weeks. Diazepam and other drugs in this class can be habit-forming. Diazepam can become a drug of abuse and should be used with caution in patients with history of substance abuse. People taking diazepam should not stop taking the drug abruptly. This can lead to withdrawal effects such as shaking, stomach cramps, nervousness, and irritability.
Side effects


|Heavy || 15-30mg+
Anxiety, irregular heartbeat, forgetfulness, mental depression, and confusion are side effects that could require prompt medical attention. However, these side effects are not common when taking diazepam. Even less common, but serious events, are behavior changes, low blood pressure, muscle weakness, and the yellowing of the eyes or skin (jaundice). More common, but less serious side effects, include drowsiness, clumsiness, slurred speech, and dizziness. Rare among these less serious side effects are stomach cramps, headache, muscle spasm, nausea, vomiting, and dry mouth.


|}
Once a person stops taking diazepam, the following side effects could occur from withdrawal: sleeping difficulties, nervousness, and irritability. Less common side effects from withdrawal include confusion, abdominal cramps, mental depression, sensitivity to light, nausea, shaking, and increased sweating. Rarely seen side effects include seizures, hallucinations, and feelings of distrust in the patient.
 
= Duration =
Note: Duration can be significantly longer with higher doses.
{| class="wikitable"
|+ Oral
|-
| Onset || 30-90 Minutes
|-
| Total || Up to 24 hours, Main effects are generally felt for roughly 8-12 hours.
|}


== Interactions ==


= Effects =
Diazepam interacts with a long list of other medications. Anyone starting this drug should review the other medications they are taking with their physician and pharmacist for possible interactions. Patients should always inform all their health care providers, including dentists, that they are taking diazepam. Diazepam can add to the depressive effects of other central nervous system depressant drugs (for example, alcohol, other tranquilizers, or sleeping pills) when taken together. In severe cases, this can result in death.
== Positive ==
*Euphoria
*Relaxation
*Anti-Anxiety effects


== Neutral ==
Several drugs reduce the ability of diazepam to be broken down and cleared from the body. This results in higher levels of the drug in the blood and increases the probability that side effects will occur. These drugs include several antibiotics, such as erythromycin, anti-stomach acid drugs, such as cimetidine (Tagamet), and antifungal drugs, such as fluconazole. [[Alcohol]] should not be used when taking diazepam and other benzodiazepine drugs. Other drugs that are used to treat mental disorders should not be combined with diazepam unless the patient is under the careful supervision and monitoring of a doctor.
*Drowsiness
*Appetite fluctuation


== Negative ==
*Memory loss
*Blackout potential
*Motor skill impairment
*Dizziness
*Depression
*Irritability, aggression, rage
*Personality changes
*Emotional and social dissociation or de-realization (long term use)


= Harm Reduction =
== Diazepam Brand Names ==
When on high doses of [[Benzodiazepines|benzodiazepines]], users are likely to black out and potentially hurt themselves through a variety of adventures. If you are using it as a sleep aid, it's recommended to continue doing what you're doing until you begin to feel drowsy, then go to bed.
Some users report Diazepam (and [[Benzodiazepines|benzodiazepines]] in general) to lead to compulsive redosing, trying to find a “high” which is where a fair amount of the point above comes from. To avoid this keep doses low and be wary of reduced inhibitions while under the influence of Diazepam.
== Interactions ==
As with other depressants, Diazepam should not be combined with any other CNS depressants (such as [[Alcohol]]), at the risk of respiratory depression, which can lead to death.


See the [[Drug combinations]] chart for more information.
=== U.S ===


= Chemistry and Pharmacology =
*Diastat®
Diazepam can be administered orally, intravenously (Has to be diluted, as it is painful and damaging to veins), intramuscularly, or as a suppository.
*Diazepam Intensol®
Peak plasma levels occur between 30 and 90 minutes after oral administration and between 30 and 60 minutes after intramuscular administration; 10-45 minutes for Rectal, and between 1-5 minutes intravenously.
*Valium®
Diazepam is highly protein-bound, with 95-99% of the absorbed drug being protein-bound.
Diazepam is highly lipid-soluble, and is widely distributed throughout the body after administration. It easily crosses the blood-brain-barrier. After absorption, diazepam is redistributed into muscle and adipose tissue. Continual dialy doses of Diazepam quickly build to a high concentration in the body (mainly in adipose tissue)
Diazepam unergoes oxifative metabolism by demethylation (CYP 2C9, 2C19, 2B6, 3A4, and 3A5) hydroxylation (CYP 3A4 and 2C19) and glucuronidation in the liver as part of the cytochrome P450 enzyme system.
The main active metabolite of diazepam is Desmethyldiazepam (Nordiazepam) Other metabolites inclue minor active metolites temazepam and oxazepam. 


= Legal Status =
=== Canada ===
== International ==


Diazepam is a schedule IV controlled drug under the Convention on Psychotropic Substances.
*Apo-Diazepam®
== UK ==
*Diastat®
*Diazemuls®
*Valium®


Classified as a Class C drug.
=== Other Countries ===
*Alboral® (MX)
*Aliseum® (IT)
*Ansilive® (BR)
*Ansiolin® (IT)
*Antenex® (AU)
*Anxicalm® (IE)
*Apaurin® (CZ, HR, RU, SI)
*Apo-Diazepam® (CA, CZ, SG)
*Apozepam® (DK, SE)
*Assival® (IL)
*Azepam® (TH)
*Bensedin® (YU)
*Benzopin® (ZA)
*Bialzepam® (EC, PT)
*Calmociteno® (BR)
*Calmpose® (IN, RU, ZA)
*Cercine® (JP)
*Compaz® (BR)
*Condition® (JP)
*Cuadel® (AR)
*Daiv® (AR)
*Dezepan® (AR)
*Dialar® (GB)
*Dialudon® (BR)
*Diano® (TH)
*Diapam® (FI, RU, TH, TR)
*Diapine® (SG, TH)
*Diastat® (CA)
*Diazem® (TR)
*Diazemuls® (AU, CA, GB, HK, IT, NL, NZ)
*Diazep AbZ® (DE)
*Diazepam-Armedica® (RO)
*Diazepam® (AU, BG, BR, CL, CZ, DE, GB, HR, IT, NZ, PL, RO, RU, YU)
*Diazepam Biocrom® (AR)
*Diazepam Bouzen® (AR)
*Diazepam Dak® (DK)
*Diazepam DBL® (SG)
*Diazepam Desitin® (CH, CZ, DE, DK, FI, HR, HU, IL, NO, RO, SE, SG, TR)
*Diazepam Drawer® (AR)
*Diazepam Ecar® (CO)
*Diazepam EG® (BE)
*Diazepam-Eurogenerics® (LU)
*Diazepam Fabra® (AR)
*Diazepam-Feltrex® (DO)
*Diazepam Injection® (GB)
*Diazepam Lacefa® (AR)
*Diazepam Larjan® (AR)
*Diazepam L.CH.® (CL)
*Diazepam Leo® (ES)
*Diazepam-Lipuro® (DE, PL)
*Diazepam Normon® (ES)
*Diazepam NQ® (BR)
*Diazepam Prodes® (ES)
*Diazepam-ratiopharm® (BE, DE, LU)
*Diazepam Rectubes® (GB, IL)
*Diazépam Renaudin® (FR)
*Diazepam Sandoz® (DE)
*Diazepam Stada® (DE)
*Diazepan® (EG)
*Diazepan Medipharma® (AR)
*Diazephar® (BE)
*diazep von ct® (DE)
*Diazerekt® (PL)
*Diaz® (IL)
*Dicam® (RU)
*Dienpax® (BR)
*Dipaz® (EC)
*Dipezona® (AR)
*Distensar® (CO)
*Dizan® (TH)
*Dizepam® (TH)
*Doval® (ZA)
*D-Pam® (NZ)
*Ducene® (AU)
*Easium® (BD)
*Evalin® (BD)
*Fabotranil® (AR)
*Faustan® (DE)
*Fizepam® (BD)
*G-Diazepam® (BD)
*Gewacalm® (AT)
*Glutasedan® (AR)
*Gradual® (AR)
*Hexalid® (DK)
*Horizon® (JP)
*Kiatrium® (BR)
*Kratium® (HK)
*Lamra® (DE)
*Lembrol® (AR)
*Lizan® (TR)
*Lovium® (ID)
*Medipam® (FI)
*Mentalium® (ID)
*Micronoan® (IT)
*Nervium® (TR)
*Noan® (BR, IT)
*Normabel® (HR)
*Ortopsique® (MX)
*Pacitran® (MX)
*Placidox-2® (IN)
*Plidan® (AR)
*Plidex® (AR)
*Propam® (NZ)
*Psicotran® (AR)
*Psychopax® (AT, CH)
*Q-Med Diazepam® (ZA)
*Relanium® (BG, PL)
*Relsed® (PL)
*Remedium® (CY)
*Rimapam® (GB)
*Rozam® (BD)
*Rupediz® (AR)
*Saromet® (AR)
*Sedabenz® (YU)
*Sedapen® (BD)
*Sedex® (BD)
*Sedil® (BD)
*Sedium® (BD)
*Sedulin® (BD)
*Seduxen® (BD, CZ, HU, RU)
*Serenzin® (JP)
*Sico Relax® (ES)
*Sipam® (TH)
*Stesolid® (AT, CH, CY, CZ, DE, DK, EG, ES, FI, GB, HU, ID, IE, IL, JO, KW, LB, NL, NO, PT, SE, SG, TH)
*Stesolid Novum® (SE)
*Stesolid Rectal Tubes® (GB, TH)
*Tensium® (GB)
*Tranquase® (DE)
*Tranquirit® (IT)
*Umbrium® (AT)
*Uniao Diazepam® (BR)
*Unisedil® (PT)
*Valaxona® (DK)
*Valclair® (GB)
*Valiquid® (DE)
*Valisanbe® (ID)
*Valium® (AR, AU, BE, BR, CA, CL, CR, DE, DK, DO, ES, GB, GT, HK, HN, HR, ID, IE, IN, IT, LU, MX, NL, NO, PA, PL, PT, SV, TH, ZA)
*Valium Roche® (AT, CH, DE, FR, PL, RU)
*Valix® (BR)
*Valocordin-Diazepam® (DE)
*Vatran® (IT)
*V-Day Zepam® (TH)
*Vival® (NO)
*Zopam® (TH)


[[Category:Chemicals]]


{{Benzodiazepines}}
[[Category:Drugs]]
[[Category:Drugs]]
 
[[Category:Medicine]]
[[Category:Depressant]]
[[Category:Benzodiazepines]]

Revision as of 10:51, 31 December 2018

Diazepam is actually pretty much the same as Valium. Diazepam is a mild tranquilizer in the class of drugs known as benzodiazepines. The generic form of this drug is also available.

Diazepam 10mg tabs

Use of Diazepam

Diazepam is used on a short-term basis to treat patients with mild to moderate anxiety. It is also used to treat some types of seizures (epilepsy), muscle spasms, nervous tension, and symptoms relating to alcohol withdrawal. Description

Diazepam is one of many chemically-related tranquilizers in the class of drugs called benzodiazepines. Benzodiazepines are sedative-hypnotic drugs that help to relieve nervousness, tension, and other anxiety symptoms by slowing the central nervous system. To do this, they block the effects of a specific chemical involved in the transmission of nerve impulses in the brain, decreasing the excitement level of the nerve cells. All benzodiazepines, including diazepam, cause sedation, drowsiness, and reduced mental and physical alertness. Recommended dosage

The typical dose of diazepam used to treat anxiety or seizures in healthy adults ranges from a total of 6 milligrams (mg) to 40 mg per day given in three or four doses. Elderly people (over age 60) are usually given lower doses in the range of 4–10 mg per day to treat anxiety or nervous tension. For acute treatment of seizures, a higher dose of diazepam is given intravenously (directly into the vein) only in a controlled medical setting such as a hospital or emergency room. For alcohol withdrawal, the typical dose is a total of 30–40 mg per day given in three or four doses.

The typical dose for a child over age six months with anxiety or seizures is a total of 3–10 mg per divided into several doses. In general, children receive lower doses of diazepam even when they have a body weight equivalent to a small adult. Diazepam is usually taken as a pill, but an injectable form is sometimes used when a serious seizure is in progress or when muscle spasms are severe. There is also a liquid oral form of the drug available.

Diazepam
Systematic (IUPAC) name
7-chloro-1,3dihydro-1-methyl-
5-phenyl-2H-
1,4-benzodiazepin-2-one
Identifiers
CAS number 439-14-5
ATC code N05BA01 N05BA17
PubChem 3016
DrugBank APRD00642
ChemSpider 2908
Chemical data
Formula C16H13ClN2O 
Mol. mass 284.7 g/mol
Pharmacokinetic data
Bioavailability 93%
Metabolism Hepatic - CYP2C19
Half life 20–100 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C(AU) D(US)

Legal status

Prescription Only (S4)(AU) Schedule IV(CA) Schedule IV(US) Schedule IV (International)

Routes Oral, IM, IV, suppository


Precautions

The elderly, children, and those with significant health problems need to be carefully evaluated before receiving diazepam. Children under the age of six months should not take diazepam. In addition, people with a history of liver disease, kidney disease, or those with low levels of a protein in the blood called albumin need to be carefully assessed before starting this drug.

People taking diazepam should not drive, operate dangerous machinery, or engage in hazardous activities that require mental alertness, because diazepam can cause drowsiness. Alcohol and any drugs that treat mental illness should not be used when taking this medication. People who have previously had an allergic reaction to any dosage level of diazepam or any other benzodiazepine drug should not take diazepam. People with acute narrow-angle glaucoma should not take diazepam.

The prescribing physician should be consulted regularly if diazepam is taken consistently for more than two weeks. Diazepam and other drugs in this class can be habit-forming. Diazepam can become a drug of abuse and should be used with caution in patients with history of substance abuse. People taking diazepam should not stop taking the drug abruptly. This can lead to withdrawal effects such as shaking, stomach cramps, nervousness, and irritability. Side effects

Anxiety, irregular heartbeat, forgetfulness, mental depression, and confusion are side effects that could require prompt medical attention. However, these side effects are not common when taking diazepam. Even less common, but serious events, are behavior changes, low blood pressure, muscle weakness, and the yellowing of the eyes or skin (jaundice). More common, but less serious side effects, include drowsiness, clumsiness, slurred speech, and dizziness. Rare among these less serious side effects are stomach cramps, headache, muscle spasm, nausea, vomiting, and dry mouth.

Once a person stops taking diazepam, the following side effects could occur from withdrawal: sleeping difficulties, nervousness, and irritability. Less common side effects from withdrawal include confusion, abdominal cramps, mental depression, sensitivity to light, nausea, shaking, and increased sweating. Rarely seen side effects include seizures, hallucinations, and feelings of distrust in the patient.

Interactions

Diazepam interacts with a long list of other medications. Anyone starting this drug should review the other medications they are taking with their physician and pharmacist for possible interactions. Patients should always inform all their health care providers, including dentists, that they are taking diazepam. Diazepam can add to the depressive effects of other central nervous system depressant drugs (for example, alcohol, other tranquilizers, or sleeping pills) when taken together. In severe cases, this can result in death.

Several drugs reduce the ability of diazepam to be broken down and cleared from the body. This results in higher levels of the drug in the blood and increases the probability that side effects will occur. These drugs include several antibiotics, such as erythromycin, anti-stomach acid drugs, such as cimetidine (Tagamet), and antifungal drugs, such as fluconazole. Alcohol should not be used when taking diazepam and other benzodiazepine drugs. Other drugs that are used to treat mental disorders should not be combined with diazepam unless the patient is under the careful supervision and monitoring of a doctor.


Diazepam Brand Names

U.S

  • Diastat®
  • Diazepam Intensol®
  • Valium®

Canada

  • Apo-Diazepam®
  • Diastat®
  • Diazemuls®
  • Valium®

Other Countries

  • Alboral® (MX)
  • Aliseum® (IT)
  • Ansilive® (BR)
  • Ansiolin® (IT)
  • Antenex® (AU)
  • Anxicalm® (IE)
  • Apaurin® (CZ, HR, RU, SI)
  • Apo-Diazepam® (CA, CZ, SG)
  • Apozepam® (DK, SE)
  • Assival® (IL)
  • Azepam® (TH)
  • Bensedin® (YU)
  • Benzopin® (ZA)
  • Bialzepam® (EC, PT)
  • Calmociteno® (BR)
  • Calmpose® (IN, RU, ZA)
  • Cercine® (JP)
  • Compaz® (BR)
  • Condition® (JP)
  • Cuadel® (AR)
  • Daiv® (AR)
  • Dezepan® (AR)
  • Dialar® (GB)
  • Dialudon® (BR)
  • Diano® (TH)
  • Diapam® (FI, RU, TH, TR)
  • Diapine® (SG, TH)
  • Diastat® (CA)
  • Diazem® (TR)
  • Diazemuls® (AU, CA, GB, HK, IT, NL, NZ)
  • Diazep AbZ® (DE)
  • Diazepam-Armedica® (RO)
  • Diazepam® (AU, BG, BR, CL, CZ, DE, GB, HR, IT, NZ, PL, RO, RU, YU)
  • Diazepam Biocrom® (AR)
  • Diazepam Bouzen® (AR)
  • Diazepam Dak® (DK)
  • Diazepam DBL® (SG)
  • Diazepam Desitin® (CH, CZ, DE, DK, FI, HR, HU, IL, NO, RO, SE, SG, TR)
  • Diazepam Drawer® (AR)
  • Diazepam Ecar® (CO)
  • Diazepam EG® (BE)
  • Diazepam-Eurogenerics® (LU)
  • Diazepam Fabra® (AR)
  • Diazepam-Feltrex® (DO)
  • Diazepam Injection® (GB)
  • Diazepam Lacefa® (AR)
  • Diazepam Larjan® (AR)
  • Diazepam L.CH.® (CL)
  • Diazepam Leo® (ES)
  • Diazepam-Lipuro® (DE, PL)
  • Diazepam Normon® (ES)
  • Diazepam NQ® (BR)
  • Diazepam Prodes® (ES)
  • Diazepam-ratiopharm® (BE, DE, LU)
  • Diazepam Rectubes® (GB, IL)
  • Diazépam Renaudin® (FR)
  • Diazepam Sandoz® (DE)
  • Diazepam Stada® (DE)
  • Diazepan® (EG)
  • Diazepan Medipharma® (AR)
  • Diazephar® (BE)
  • diazep von ct® (DE)
  • Diazerekt® (PL)
  • Diaz® (IL)
  • Dicam® (RU)
  • Dienpax® (BR)
  • Dipaz® (EC)
  • Dipezona® (AR)
  • Distensar® (CO)
  • Dizan® (TH)
  • Dizepam® (TH)
  • Doval® (ZA)
  • D-Pam® (NZ)
  • Ducene® (AU)
  • Easium® (BD)
  • Evalin® (BD)
  • Fabotranil® (AR)
  • Faustan® (DE)
  • Fizepam® (BD)
  • G-Diazepam® (BD)
  • Gewacalm® (AT)
  • Glutasedan® (AR)
  • Gradual® (AR)
  • Hexalid® (DK)
  • Horizon® (JP)
  • Kiatrium® (BR)
  • Kratium® (HK)
  • Lamra® (DE)
  • Lembrol® (AR)
  • Lizan® (TR)
  • Lovium® (ID)
  • Medipam® (FI)
  • Mentalium® (ID)
  • Micronoan® (IT)
  • Nervium® (TR)
  • Noan® (BR, IT)
  • Normabel® (HR)
  • Ortopsique® (MX)
  • Pacitran® (MX)
  • Placidox-2® (IN)
  • Plidan® (AR)
  • Plidex® (AR)
  • Propam® (NZ)
  • Psicotran® (AR)
  • Psychopax® (AT, CH)
  • Q-Med Diazepam® (ZA)
  • Relanium® (BG, PL)
  • Relsed® (PL)
  • Remedium® (CY)
  • Rimapam® (GB)
  • Rozam® (BD)
  • Rupediz® (AR)
  • Saromet® (AR)
  • Sedabenz® (YU)
  • Sedapen® (BD)
  • Sedex® (BD)
  • Sedil® (BD)
  • Sedium® (BD)
  • Sedulin® (BD)
  • Seduxen® (BD, CZ, HU, RU)
  • Serenzin® (JP)
  • Sico Relax® (ES)
  • Sipam® (TH)
  • Stesolid® (AT, CH, CY, CZ, DE, DK, EG, ES, FI, GB, HU, ID, IE, IL, JO, KW, LB, NL, NO, PT, SE, SG, TH)
  • Stesolid Novum® (SE)
  • Stesolid Rectal Tubes® (GB, TH)
  • Tensium® (GB)
  • Tranquase® (DE)
  • Tranquirit® (IT)
  • Umbrium® (AT)
  • Uniao Diazepam® (BR)
  • Unisedil® (PT)
  • Valaxona® (DK)
  • Valclair® (GB)
  • Valiquid® (DE)
  • Valisanbe® (ID)
  • Valium® (AR, AU, BE, BR, CA, CL, CR, DE, DK, DO, ES, GB, GT, HK, HN, HR, ID, IE, IN, IT, LU, MX, NL, NO, PA, PL, PT, SV, TH, ZA)
  • Valium Roche® (AT, CH, DE, FR, PL, RU)
  • Valix® (BR)
  • Valocordin-Diazepam® (DE)
  • Vatran® (IT)
  • V-Day Zepam® (TH)
  • Vival® (NO)
  • Zopam® (TH)


 
Benzodiazepines (N05BA, N05CD)
1,4-Benzodiazepines
1,5-Benzodiazepines
2,3-Benzodiazepines
Triazolobenzodiazepines
Imidazobenzodiazepines
Oxazolobenzodiazepines
Thienodiazepines
Pyridodiazepines
Pyrazolodiazepines
Pyrrolodiazepines
Benzodiazepine Prodrugs
Others
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